Transcriptomics,Genomics

Dataset Information

151

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells


ABSTRACT: Identify genes that are differentially regulated as a consequence of restoration of full-length functional APC in a colorectal cancer cell lines. Overall design: Examine mRNA expression level changes between SW480 (APC defective) and SW480+APC (SW480 cells with restored functional APC) cells, whilst accounting for any non-specific expression changes by comparison to SW480+control vector.

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Oliver Sieber 

PROVIDER: GSE76307 | GEO | 2016-02-01

SECONDARY ACCESSION(S): PRJNA306863

REPOSITORIES: GEO

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Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells.

King Lauren E LE   Love Christopher G CG   Sieber Oliver M OM   Faux Maree C MC   Burgess Antony W AW  

Genomics data 20160203


The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in about 80% of colorectal cancers (CRC) Brannon et al. (2014) [1]. APC is a large multifunctional protein that regulates many biological functions including Wnt signalling (through the regulation of beta-catenin stability) Reya and Clevers (2005) [2], cell migration Kroboth et al. (2007), Sansom et al. (2004) [3], [4], mitosis Kaplan et al. (2001) [5], cell adhesion Faux et al. (2004), Carothers et al. (2001) [6], [7] and di  ...[more]

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