Genomics

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Single cell analysis defines the divergence between the innate lymphoid cell and lymphoid tissue inducer lineages


ABSTRACT: The precise lineage relationships between innate lymphoid cells (ILC) and the lymphoid tissue inducer (LTi) are poorly understood. Using single-cell multiplex transcriptional analysis of 100 lymphoid genes and single-cell cultures of fetal liver precursor cells, we identified the common proximal precursor to these lineages and showed that its bifurcation was precisely marked by the differential induction of the transcription factors PLZF and TCF1. Acquisition of individual ILC1/2/3-specific effector programs was initiated later, at the common ILC precursor (ILCP) stage, by transient expression of mixed ILC1/2/3 transcriptional patterns whereas, in contrast, LTi development did not go through multilineage priming. These findings provide novel insights into divergent mechanisms of ILC and LTi lineage differentiation and establish a high-resolution map of their development.

ORGANISM(S): Mus musculus

PROVIDER: GSE76407 | GEO | 2015/12/30

SECONDARY ACCESSION(S): PRJNA307194

REPOSITORIES: GEO

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