Ontology highlight
ABSTRACT:
INSTRUMENT(S): [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
SUBMITTER: Tommaso Mazza
PROVIDER: GSE76422 | GEO | 2017-03-07
SECONDARY ACCESSION(S): PRJNA307251
REPOSITORIES: GEO
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Binda Elena E Visioli Alberto A Giani Fabrizio F Trivieri Nadia N Palumbo Orazio O Restelli Silvia S Dezi Fabio F Mazza Tommaso T Fusilli Caterina C Legnani Federico F Carella Massimo M Di Meco Francesco F Duggal Rohit R Vescovi Angelo L AL
Cancer research 20161223 4
Brain invasion by glioblastoma determines prognosis, recurrence, and lethality in patients, but no master factor coordinating the invasive properties of glioblastoma has been identified. Here we report evidence favoring such a role for the noncanonical WNT family member Wnt5a. We found the most invasive gliomas to be characterized by Wnt5a overexpression, which correlated with poor prognosis and also discriminated infiltrating mesenchymal glioblastoma from poorly motile proneural and classical g ...[more]