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CRC cells_Aspirin treatment_48 hours_Rep8

ABSTRACT: To identify the lncRNA profiles of colorectal carcinoma cells treated with aspirin, we performed microarray analysis using primary cultured cancer cells obtained from 8 clinical CRC tissues. After the CRC cells were treated with aspirin for 48 hours, 28 lncRNAs were statistically up-regulated more than 2-fold.

ORGANISM(S): Homo sapiens

PROVIDER: GSE76583 | GEO | 2016/01/07

SECONDARY ACCESSION(S): PRJNA308099

REPOSITORIES: GEO

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CRC cells_Aspirin treatment_48 hours_Rep8

Project description:To identify the lncRNA profiles of colorectal carcinoma cells treated with aspirin, we performed microarray analysis using primary cultured cancer cells obtained from 8 clinical CRC tissues. After the CRC cells were treated with aspirin for 48 hours, 28 lncRNAs were statistically up-regulated more than 2-fold. We treated the primary cultured cancer cells obtained from 8 clinical CRC tissues with DMSO (negative control group_Rep8) and aspirin (Experiment group_Rep8).

2016-01-07 | E-GEOD-76583 | biostudies-arrayexpress

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lncRNA expression of CRC liver metastasis

Project description:The purpose of this study is to identify lncRNAs involved in the pathology of colorectal cancer (CRC) liver metastasis and investigate their underlying mechanisms. A total of 439 miRNAs were identified to be differentially expressed between 7 primary CRC tissues with liver metastases and 8 CRC tissues without liver metastases from 15 patients by Arraystar lncRNA microarrays

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Project description:Radiotherapy is essential to treat colorectal cancer (CRC) although the tolerance of which is of quite common occurrence in clinic. Long noncoding RNA (lncRNA) and circular RNA (circRNAs) have an important role in the radio-resistance of CRC through regulating targeted genes or proteins expression at either transcriptional or post-translational levels. In this study, we aimed to seek out novel lncRNAs and circRNAs involved in radio-resistance by RNA-seq analysis of 8 radiosensitive and 8 radioresistant CRC patients.

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Project description:Identifying the exact molecules associated with CRC metastasis may be crucial to understand the process, which might also be translated to the diagnosis and treatment of CRC. In this study, we investigate the association of microRNA expression patterns with the lymph node metastasis of colorectal cancer. To investigate the association of microRNA expression patterns with the lymph node metastasis of colorectal cancer, eight primary colorectal cancer tissues derived from stage II–III colorectal cancer patients with (n = 4) or without (n = 4) lymph node metastasis were collected and the miRNA expression profiles of them were determined using Agilent miRNA microarray. Different miRNA expression profiles were identified in CRC tissues between lymph node metastasis positive and negative group.

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CRC lncRNA/mRNA expression

Project description:ArrayStar Human LncRNA/mRNA Expression Microarray Version 3.0 was used to detect lncRNA expression in CRC tissues compared with their matched non-tumoral tissues. Here we report significantly up-regulated as well as down-regulated lncRNAs in CRC tissues compared with their matched non-tumoral tissues.

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Transcription profile of colon biopsies from normal (NOR) donors, patients, underwent resection for CRC (M-CRC) and patients carriers of mutations predisposed to HNPCC (HNPC)

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