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Gene expression change in placental labyrinth zone from Pregnancy-Associated Hypertension (PAH) mice with different Nrf2 expression.

ABSTRACT: We analyzed differences in placental gene expressions. We examined the mRNA expression profile in placental labyrinth zone from normal pregnant mice, and PAH mice with different Nrf2 expressions (WT, Nrf2 Knockout [KO], Keap1 Knockdown [KD]) Overall design: Human Angiotensinogen (hAGT) transgenic female mice showes perinatal hypertension (PAH mice) by mating male human Renin (hREN) transgenic mice. But hAGT female mice did not showes gestational hypertension (Normal pregnancy; NP mice) by mating male hAGT mice. We performed microarray analyses using placental labyrinth zone from NP mice and three types of PAH mice with different Nrf2 expression(PAH mice, PAH-Nrf2KO mice PAH-Keap1KD mice), n = 2 each.

INSTRUMENT(S): Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)

SUBMITTER: Masahiro Nezu 

PROVIDER: GSE76669 | GEO | 2017-01-01



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