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Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing

ABSTRACT: We used RNA-seq to compare the gene expression profiles of adult mouse prostate luminal cells and luminal cells that have the androgen receptor (AR) gene deleted. Our analyses show that AR-null luminal cells have altered expression levels of genes involved in cell-matrix adhesion, cytoskeleton regulation, and MAPK and TGF-beta signaling pathways. These results are consistent with our finding that AR-null luminal cells have abnormal cell morphology and loss of cell polarity.

ORGANISM(S): Mus musculus

PROVIDER: GSE76724 | GEO | 2017/01/17

SECONDARY ACCESSION(S): PRJNA308459

REPOSITORIES: GEO

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Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing.

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