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Gene expresssion changes associated to diet induced fatty liver in hamster

ABSTRACT: Our aim was to study the gene expression changes associated to the development of non hepatic steatohepatitis from simple steatosis in a model of diet induced obesity in hamster (mesocricetus auratus)

ORGANISM(S): Mesocricetus auratus

PROVIDER: GSE76725 | GEO | 2016/07/14

SECONDARY ACCESSION(S): PRJNA308464

REPOSITORIES: GEO

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Changes in golden Syrian hamster HDL proteome caused by altered cholesteryl ester transfer protein expression

Project description:Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester (CE) and triglyceride (TG) between lipoproteins, which alters lipoprotein metabolism. Hamster and human CETPs have very different preferences for CE versus TG as substrate. To assess the impact of altering CETP’s substrate preference on lipoproteins in vivo, human CETP was expressed in hamsters (Mesocricetus auratus). Chow-fed hamsters received adenoviruses expressing no CETP (Ad-Null), hamster CETP (Ad-hamster CETP) or human CETP (Ad-human CETP). High density lipoproteins were isolated from hamster plasma 6 days after adenovirus injection by ultracentrifugation as the 1.063 - 1.21 g/ml density fraction. HDL proteins were precipitated with cold acetone and subjected to LC+MS/MS analysis

2020-06-25 | PXD017998 | Pride

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

Project description:COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appeared first in Wuhan, Hubei, China, has emerged as a global health concern claiming millions of lives worldwide. Syrian golden hamster (Mesocricetus auratus) has emerged as a suitable model as when infected by SARS-CoV-2, manifests lung pathology resembling human COVID-19 patients. In this study, we employed a quantitative approach to study the proteomic changes in the SARS-CoV-2-infected lung tissue. The samples were analyzed using Orbitrap Fusion Tribrid mass spectrometer in triplicates and the data acquired was searched against Mesocricetus auratus protein database which resulted in the identification of nearly 2,000 non-redundant proteins. The outcome of this study will facilitate in discovery of potential candidate biomarkers for predicting disease course and warrants their further validation in human patient samples.

2021-11-03 | PXD024547 | Pride

MicroRNA expression profiles in different tissues from normolipidemic hamster and high-fat diet induced hyperlipidemic hamster (Mesocricetus auratus)

Project description:MicroRNA expression profiles in different tissues from normolipidemic hamster and high-fat diet induced hyperlipidemic hamster (Mesocricetus auratus)

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Quantitative Analysis of Transcriptomes of Hamster Liver Treated with or without DC371739

Project description:Purpose: The goal of this study is to reveal the transcriptional dynamics of hamster liver upon DC371739 treatment Methods: Total RNAs were extracted from the livers of HFD-hamsters control and DC371739-treated (30 mg/kg for 21 days) hamsters. Seven biological replicates were performed for each studied condition. The libraries were sequenced using NovaSeq 6000 (pair-end 150 bp). All reads were mapped to the reference genome of Mesocricetus auratus using HISAT2 v.2.2.1 as instructed. RNA counts were generated from feature Counts. Results: Ccompared with the vehicle group, the transcription levels of Pcsk9 and Angptl3 of the DC371739 treated group have been decreased by 41.3% (P = 0.016) and 15.7% (P = 0.031), respectively, while the transcription levels of Hnf1α and Ldlr have not shown the statistically significant difference after DC371739 treatment. Conclusions: We conclude that DC371739 negatively modulates the transcription of two crucial therapeutic targets PCSK9 and ANGPTL3 for hypercholesterolemia treatment.

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Liver transcriptomic and methylomic analyses identify transcriptional MAPK regulation in facultative hibernation of Syrian hamster [WGBS]

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2023-05-02 | GSE199815 | GEO

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Liver transcriptomic and methylomic analyses identify transcriptional MAPK regulation in facultative hibernation of Syrian hamster [RNA-Seq]

Project description:Hibernation consist of alternating torpor/arousal phases, during which animals cope with repetitive hypothermia and ischemia-reperfusion. Due to limited transcriptomic and methylomic information for facultative hibernators, we here conducted RNA and whole genome bisulfite sequencing in liver of hibernating Syrian hamster (Mesocricetus auratus). Gene Ontology analysis was performed on 844 differentially expressed genes (DEGs) and confirmed the Liver, shift in metabolic fuel utilization, inhibition of RNA transcription and cell cycle regulation as found in seasonal hibernators. We Liver, show a so far unreported suppression of MAPK and PP1 pathways. Notably, hibernating hamsters Liver, showed upregulation of MAPK inhibitors (DUSPs and SPRYs) and reduced levels of MAPK induced transcription factors. Promoter methylation was found to modulate the expression of genes targeted by these transcription factors. In conclusion, we document gene regulation between hibernation phases, which may aid the identification of pathways and targets to prevent organ damage in transplantation or ischemia-reperfusion.

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Expression data from human non-alcoholic fatty liver disease stages

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