Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from thalamic nuclei in control and bilateral enucleated mice at P0 and P4

ABSTRACT: Elimination of peripheral retinal axons leads to changes in gene expression in both visual and somatosensory thalamic neurons. We used microarrays to determine the global programme of gene expression underlying peripheral input deprivation and identify candidate thalamic genes involved in cross-modal plasticity.

ORGANISM(S): Mus musculus

PROVIDER: GSE76767 | GEO | 2017/01/30

SECONDARY ACCESSION(S): PRJNA308561

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data from thalamic dLGN nucleus in control and Sema6A knock-out mice at P0

Project description:Misguided visual thalamic axons leads to changes in gene expression in visual thalamic neurons. We used microarrays to determine the global programme of gene expression due to altered connectivity.

2016-09-21 | GSE79683 | GEO

Transcriptomic atlas of thalamic nuclei

Project description:We profiled the transcriptome of 22 thalamic nuclei. Nuclei were retrogradely labeled from their forebrain target areas, microdissected and fluorescent cells pooled. Anterograde tracing was used when identification of nuclear boundaries was ambiguous. We found that thalamic nuclei share a common axis of variance closely linked to the mediolateral spatial axis of thalamus. This axis was enriched in functionally relevant genes such as neurotransmitter receptors and ion channels, and was closely linked to functional and morphological properties of the neurons.

2019-08-21 | GSE133911 | GEO

Transcriptomic atlas of thalamic nuclei

Project description:Transcriptomic atlas of thalamic nuclei

| PRJNA552996 | ENA

Single-cell atlas of thalamic projection systems

Project description:We collected single-cell RNAseq data from neurons of five thalamocortical projection systems (motor, somatosensory, visual, auditory, and prefrontal). Cells of each projection system were retrogradely labeled from their cortical target area, microdissected, and collected individually. By combining single-cell transcriptomics with in situ RNA hybridization, we found heterogeneity not only between thalamic nuclei but also within nuclei, with graded transitions between cell identities.

2019-08-21 | GSE133912 | GEO

Developmental trajectories of thalamic nuclei revealed by single-cell transcriptome profiling and Shh perturbation

Project description:The thalamus is the principal information hub of the vertebrate brain, with essential roles in sensory and motor information processing, attention, and memory. The complex array of thalamic nuclei develops from a restricted pool of neural progenitors. We apply longitudinal single-cell RNA-sequencing and regional abrogation of Sonic hedgehog (Shh) to map the developmental trajectories of thalamic progenitors, intermediate progenitors, and post-mitotic neurons as they coalesce into distinct thalamic nuclei. These data reveal that the complex architecture of the thalamus is established early during embryonic brain development through the coordinated action of four cell differentiation lineages derived from Shh-dependent and independent progenitors. We systematically characterize the gene expression programs that define these thalamic lineages across time and demonstrate how their disruption upon Shh depletion causes pronounced locomotor impairment resembling infantile Parkinson’s disease. These results reveal key principles of thalamic development and provide mechanistic insights into neurodevelopmental disorders resulting from thalamic dysfunction.

2022-10-16 | GSE211701 | GEO

Transcriptomic landscape of the anterior thalamic nuclei of the mouse

Project description:Here, we examined diversity in the cell-type composition of the mouse anterior thalamic nuclei (ATN) using single-cell RNA-seq.

2024-01-28 | GSE227627 | GEO

Transcriptomic landscape of the anterior thalamic nuclei of the mouse [Xenium]

Project description:Here, we examined diversity in the cell-type composition of the mouse anterior thalamic nuclei (ATN) using single-cell RNA-seq and single-cell spatial transcriptomics.

2024-02-17 | GSE255953 | GEO

Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Single-cell RNA-seq was performed in SHH-treated thalamic organoids

2023-03-31 | GSE226333 | GEO

Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Single-cell RNA-seq was performed in SHH-treated thalamic organoids

2023-04-24 | GSE210720 | GEO

DNA methylation alteration and gene expression sigature in brainstem, thalamic, and supratentorial gliomas

Project description:Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect due to their proximity to eloquent brain structures. Here, we performed a comprehesive genomic and epigenomic study, using gene expression and methylation microarrays, to research on th different genomic and epigenetic signatures between brainstem, thalamic, and supratentorial gliomas. Comparison of brainstem, thalamic and supratentorial gliomas

2014-05-27 | E-GEOD-50774 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data