Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE76866 | GEO | 2016/10/19

SECONDARY ACCESSION(S): PRJNA308811

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory.

Project description: Not available

| S-EPMC4838502 | biostudies-literature

Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory [Nurr77]

Project description:Somatic hypermutation (SHM) and class switch recombination (CSR) increase the affinity and diversify the effector functions of antibodies during immune responses. Although SHM and CSR are fundamentally different, their independent roles in regulating B cell fate have been difficult to uncouple because a single enzyme, activation-induced cytidine deaminase (encoded by Aicda), initiates both reactions. Here, we used a combination of Aicda and antibody mutant alleles that separate the effects of CSR and SHM on polyclonal immune responses. We found that class-switching to IgG1 biased the fate choice made by B cells, favoring the plasma cell over memory cell fate without significantly affecting clonal expansion in the germinal center (GC). In contrast, SHM reduced the longevity of memory B cells by creating polyreactive specificities that were selected against over time. Our data define the independent contributions of SHM and CSR to the generation and persistence of memory in the antibody system.

2016-10-19 | GSE76865 | GEO

Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory [IgM_IgG1]

2016-10-19 | GSE76864 | GEO

Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory

Project description:Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory

| PRJNA308811 | ENA

B lymphocyte activation induces DNA methylation reprogramming and establishes a common epigenetic signature in memory B and plasma cell compartments

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-08-13 | E-GEOD-24919 | biostudies-arrayexpress

Epigenetics of lactose intolerance and lactase persistence

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-25 | E-GEOD-69979 | biostudies-arrayexpress

Regulation of B lymphocyte development by histone H2A deubiquitinase BAP1

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-29 | GSE162085 | GEO

HIC2 represses BCL11A transcription to regulate hemoglobin switching during development

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-05-25 | GSE173587 | GEO

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-12-01 | GSE107782 | GEO

Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-06 | GSE232255 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data