Manganese (II) Activates cGAS-STING pathway

ABSTRACT: We show that Manganese (II) is a potent type I-IFN inducing agonist, stimulating cells into an anti-viral state in the absence of infection. Mechanically, Mn2+ treatment led to a profound cGAS-STING-dependent innate immune activation, conferring cells or mice viral resistance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE77216 | GEO | 2018/10/09

REPOSITORIES: GEO