Genomics

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DNA copy number variation analysis in hepatoma cell lines

ABSTRACT: We analyzed specific genes for DNA copy number variation in hepatoma cells and investigated whether these factors are related to liver cancer phenotype. Chromosome 20p, which includes the ligand for Notch pathways, Jagged1, was found to be amplified in several types of hepatoma cells. In conclusion, amplification of Jagged1 contributed to mRNA expression that activates the Jagged1-Notch signaling pathway in liver cancer and led to poor outcome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE77224 | GEO | 2016/02/04

SECONDARY ACCESSION(S): PRJNA310739

REPOSITORIES: GEO

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