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Transgenic overexpression of Pla2g10

ABSTRACT: Microarray gene profiling of thymus from PLA2G10-Tg mice in comparison with that from control mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE77336 | GEO | 2016/01/29

SECONDARY ACCESSION(S): PRJNA310088

REPOSITORIES: GEO

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Transgenic overexpression of Pla2g10

Project description:Microarray gene profiling of thymus from PLA2G10-Tg mice in comparison with that from control mice. Pla2g10-Tg/+ mice and littermate controls (C57BL/6 background); 6-months old; thymus; pooled from 4 mice for each genotype.

2016-01-29 | E-GEOD-77336 | biostudies-arrayexpress

Transgenic overexpression of Pla2g10 display alopecia and epidermal hyperplasia

Project description:Microarray gene profiling of skin from PLA2G10-Tg mice in comparison with that from control mice yielded data for explaining the overall tendency of Tg skin to show hair follicle distortion and epidermal hyperplasia associated with hyperkeratosis in the absence of inflammation

2015-08-08 | GSE71827 | GEO

Transgenic overexpression of Pla2g10 display alopecia and epidermal hyperplasia

2015-08-08 | E-GEOD-71827 | biostudies-arrayexpress

Whole genome microarray gene expression profiling of transgenic mouse hearts with four-fold increased BBLN contents

Project description:The study performed whole genome microarray gene expression profiling of mouse hearts from BBLN-transgenic mice with four-fold increased cardiac BBLN (Bublin coiled coil protein) contents (Tg-BBLN-low) in comparison to non-transgenic FVB hearts. Tg-BBLN-low mice with four-fold increased cardiac BBLN expression under control of the myocardium-specific alpha-MHC promoter developed features of compensated heart failure with increasing age, which was characterized by a significantly reduced left ventricular ejection fraction as determined by echocardiography. To investigate the compensated heart failure phenotype of Tg-BBLN-low mice, whole genome micoarray gene expression profiling was performed. The microarray data show that moderately increased cardiac BBLN levels are sufficient to induce features of pathological cardiac remodeling.

2023-09-18 | GSE241030 | GEO

Gene expression profiles in cardiac specific overexpression of Glut1 transgenic mice

Project description:Cardiac-specific Glut1 transgenic (Glut1-TG) mice exhibited higher glucose uptake and utilization compared with wild type mice. Cardiac pathological hypertrophy is accompanied by a switch of substrate metabolism from fatty acid oxidation to glucose use, resulting in a fetal like metabolic profile. However, the role of increasing glucose utilization in regulating cardiomyocyte growth is poorly understood. In order to identify novel pathways that is regulated by glucose, we performed microarray analyses using hearts from Glut1-TG and WT mice. The microarray analyses revealed that many genes that are involved in branched-chain amino acids (BCAAs) were downregulated in Glut1-TG mice.

2018-05-14 | GSE110766 | GEO

Microarray analysis of transgenic mice specifically overexpressing FOXO1 in skeletal muscle (FOXO1 Tg mice)

Project description:FOXO1, a member of the FOXO forkhead type transcription factors, is markedly up-regulated in skeletal muscle during atrophy. Previously, we created transgenic mice specifically overexpressing FOXO1 in skeletal muscle (FOXO1 Tg mice). These mice weighed less than the wildtype control mice, had a reduced skeletal muscle mass. In this study, to better understand changes in skeletal muscle during atrophy, we performed a microarray analysis of skeletal muscle in wild-type control and FOXO1 Tg mice. The microarray data shows that in the skeletal muscles of FOXO1 Tg mice, gene expression of PGC-1β, a transcriptional regulator whose increased expression activates energy-expenditure-related genes in skeletal muscles, is decreased.

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Phosphoproteome analysis from BCR-ABL, MYC and CD22DE12 transgenic mouse models

2015-06-25 | GSE58873 | GEO

mRNA expression data from BCR-ABL, MYC and CD22DE12 transgenic mouse models

Project description:Leukemic splenocytes from these commercial transgenic mice that developed fatal leukemia with massive splenomegaly were isolated at the time of the necropsy and subjected to gene expression profiling and phosphoprotein profiling in side by side comparison with CD22DE12-Tg BPL or CD22DE12_BCR-ABL double transgenic cells. Mouse leukemia cells were isolated from markedly enlarged spleens of CD22DE12-Tg (N=2), BCR-ABL-Tg (N=2), Eµ-MYC Tg mice (N=2) and Splenocytes from wildtype healthy C57BL/6 mice served as controls (N=4).

2015-06-25 | E-GEOD-58872 | biostudies-arrayexpress

mRNA expression data from BCR-ABL, MYC and CD22DE12 transgenic mouse models

2015-06-25 | GSE58872 | GEO

Expression data from liver of Retnla transgenic (Tg) and non-transgenic (non-Tg) mice.

Project description:We found that Retnla-Tg mice had significantly lower serum cholesterol levels than non-Tg mice on a high-fat diet (HFD). To explore the molecular mechanisms underlying the cholesterol-lowering effects of Retnla under hyperlipidemic conditions, we subjected age- and sex-matched Retnla-Tg and non-Tg mice to a HFD for 4 weeks. Using a microarray approach, we analyzed the hepatic gene expression profiles related to cholesterol metabolism, including catabolism, biosynthesis, and transport.

2014-06-06 | GSE58214 | GEO

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