Transcriptomics,Genomics

Dataset Information

51

MiRNAs expression in HepG2 hepatocellular carcinoma cell lines: Vector Control vs. Twist1, Bcl-2, and Twist1/Bcl-2 Transfected


ABSTRACT: miRNAs profiling of HepG2 cells comparing vector-control treated HepG2 cells with HepG2 cells transfected with Twist1, Bcl-2, and Twist1/Bcl-2 plasmids. Microarray analysis revealed a panel of miRNAs with significant differential expression among these four HCC cell lines. Overall design: In the study presented here, four HCC cell lines ( HepG2-Twist1, HepG2-Bcl-2, HepG2-Twist1/Bcl-2 HCC cell lines, and HepG2-vector cell lines ) was used to analyze miRNA expression profiles. HepG2-Twist1, HepG2-Bcl-2, HepG2-Twist1/Bcl-2 HCC cell lines can stably express Twist1, Bcl-2, and Twist1/Bcl-2, respectively.

INSTRUMENT(S): MRA-1001_miRHuman_16 ( LC science)

SUBMITTER: baocun sun  

PROVIDER: GSE77501 | GEO | 2017-02-10

SECONDARY ACCESSION(S): PRJNA310642

REPOSITORIES: GEO

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Publications

Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma.

Wang Yong Y   Sun Baocun B   Zhao Xiulan X   Zhao Nan N   Sun Ran R   Zhu Dongwang D   Zhang Yanhui Y   Li Yanlei Y   Gu Qiang Q   Dong Xueyi X   Wang Meili M   An Jindan J  

Oncotarget 20160401 17


Twist1 is well known to induce epithelial-mesenchymal transition (EMT) and promote tumor metastasis. MicroRNAs (miRNAs) are involved in the EMT process and are associated with metastasis in hepatocellular carcinoma (HCC). In the present study, microRNA-26b-5p (miR-26b-5p) expression was consistently and significantly downregulated in HepG2-Twist1 HCC cell lines compared with HepG2-vector cell lines using microarrays (the HepG2-Twist1 cell line can stably express Twist1). miR-26b- 5p downregulati  ...[more]

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