Transcriptomics,Genomics

Dataset Information

39

Expression data from small intestinal eosinophils and dendritic cells

ABSTRACT: Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. We performed a global gene expression analysis to examine which genes are highly expressed by small intestinal eosinophils (CD11b+CD11c(int)MHCII-SiglecF+) compared with dendritic cells (CD11c+MHCII+). Overall design: To examine the gene expression profiles of eosinophils and dendritic cells within the small intestinal lamina propria (LP), we isolated eosinophils (CD11b+CD11c(int)MHCII-SiglecF+) and dendritic cells (CD11c+MHCII+) from the small intestinal LP of 8 week-old C57BL/6 mice by FACS, then compared the gene expression profiles between these two populations by microarray analysis.

INSTRUMENT(S): [MOE430A] Affymetrix Mouse Expression 430A Array

SUBMITTER: Myoung Ho Jang  

PROVIDER: GSE77545 | GEO | 2016-02-04

SECONDARY ACCESSION(S): PRJNA310763

REPOSITORIES: GEO

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Publications

Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the ΔdblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinop  ...[more]

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