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Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Prkar1a Fl/Fl (KO) adrenals

ABSTRACT: Prkar1a encodes one of the regulatory subunits of PKA. Prkar1a gene ablation in the adrenal cortex is associated with profound phenotypic alterations, constitutive PKA activation and reciprocal inhibition of WNT signallilng pathway We used microarrays to analyse gene expression in response to Prkar1a gene ablation

ORGANISM(S): Mus musculus

PROVIDER: GSE77630 | GEO | 2016/02/06

SECONDARY ACCESSION(S): PRJNA311055

REPOSITORIES: GEO

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Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Prkar1a Fl/Fl (KO) adrenals

Project description:Prkar1a encodes one of the regulatory subunits of PKA. Prkar1a gene ablation in the adrenal cortex is associated with profound phenotypic alterations, constitutive PKA activation and reciprocal inhibition of WNT signallilng pathway We used microarrays to analyse gene expression in response to Prkar1a gene ablation Adrenal glands were dissected from KO (4) and wild-type littermate (4) mice

2016-02-06 | E-GEOD-77630 | biostudies-arrayexpress

Expression data from mouse adrenal glands extracted from wild-type (WT) and Cyp11b2tm1.1(cre)Brlt;Prkar1afl/fl(KO) adrenals

Project description:We demonstrate that PKA signalling drives zonal conversion within adult adrenocortical lineage in a sexually dimorphic manner. Our data establish that Prkar1a genetic ablation (leading to constitutive PKA activation) in the adult adrenocortical lineage leads to endocrine hyperactivity and accelerates adrenal cortex renewal. This results in increased zona fasciculata differentiation and final conversion into reticularis-like zone. This phenomenon relies partly on sex-dependent mechanisms of cortical renewal, on which the male androgenic milieu exerts a repressive action through induction of WNT signalling, which in turn antagonizes PKA signalling and cortical cell turnover. We used microarrays to analyse gene expression in response to Prkar1a gene ablation in the adult adrenocortical cell lineage in both female and male mice and explored the effects of orchidectomy (GDX).

2017-09-16 | GSE103899 | GEO

Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Ezh2 Fl/Fl (KO) adrenals

Project description:Ezh2 encodes the catalytic subunit of the polycomb repressive complex 2 epigenetic regulator. Its ablation in the adrenal cortex results in profound alterations of adrenal homeostasis. We used microarrays to analyse gene expression in response to Ezh2 gene ablation.

2019-01-01 | GSE109578 | GEO

Expression data from 2-week and 2-month-old mouse testes extracted from wild-type (WT), Sf1:Cre,Prkar1afl/fl (prKO), Amh:Cre,Prkar1afl/fl (srKO), Cyp11a1:Cre,Prkar1afl/fl (lrKO).

Project description:Prkar1a encodes the regulatory subunit R1a of the proteine kinase A. Prkar1a ablation in the testis results in profound alterations of tissue homeostasis leading to tumor development and infertility. We used microarrays to analyze gene expression in response to Prkar1a gene ablation in testicular somatic cells (derived from SF1+ cells) (prKO model), in Sertoli cells (sKO model) or in Leydig cells (lrKO model) in 2-week and 2-month-old mouse testes.

2022-01-12 | GSE159150 | GEO

Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Ezh2 Fl/Fl (KO) adrenals

Project description:Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Ezh2 Fl/Fl (KO) adrenals

| PRJNA431418 | ENA

Human Adrenal Cortex affected by Primary Pigmented Nodular Adrenocortical Disease

Project description:Comparison between human adrenal cortex derived from adolescent female and human adrenal cortex derived from adolescent female affected by Primary Pigmented Nodular Adrenocortical Disease caused by germline mutation in PRKAR1a Keywords: other

2005-03-10 | E-GEOD-2055 | biostudies-arrayexpress

Human Adrenal Cortex affected by Primary Pigmented Nodular Adrenocortical Disease

2005-03-11 | GSE2055 | GEO

Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations

Project description:PRKAR1A inactivating mutations are responsible for primary pigmented nodular adrenocortical disease (PPNAD) whereas somatic GNAS activating mutations cause macronodular disease in the context of McCune-Albright syndrome (MAS), ACTH-independent hyperplasia (AIMAH) and, rarely, cortisol-producing adenomas (CPA). The whole-genome expression profile (WGEP) of normal (pooled) adrenals, PRKAR1A- (3) and GNAS-mutant (3) was studied. Total RNA obtained from adrenal tumors were compared to those samples obtained from normal adrenal pools

2011-11-15 | E-GEOD-33694 | biostudies-arrayexpress

SHR and WKY rat adrenal glands

Project description:We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA. Keywords: other

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Expression data from adrenal glands from normoxic and hypoxic neonatal rats

Project description:We hypothesize that changes in adrenal gene expression mediate the increased plasma corticosterone and steroidogenesis in rat pups exposed to hypoxia from birth. Keywords: effects of hypoxia on adrenal steroidogenesis in the neonatal rat

2006-11-14 | GSE6249 | GEO

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