Genomics

Dataset Information

58

Expression array of early postnatal Mt1-mmp-targeted mammary glands


ABSTRACT: Mammary gland branching morphogenesis is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases, MT1-MMP and MT2-MMP, that drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. However, the roles that these proteinases play during mammary gland development in vivo remains undefined. A mammary gland branching program that occurs during the first 10 days of early postnatal development was used to characterize the impact of global Mt1-mmp or Mt2-mmp targeting on mammary gland morphogenesis. Transcriptome profiling of ductal networks and associated stroma was used to investigate the functional roles of MT1-MMP in the early postnatal mammary gland in an unbiased fashion. Overall design: Intact mammary gland tissue was harvested from global knockout [Mt1-mmp(-/-)] mice and wild-type [Mt1-mmp(+/+)] littermates on an outbred Swiss Black background at postnatal day 10 for RNA extraction and hybridization on Affymetrix microarrays.

INSTRUMENT(S): [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate

SUBMITTER: Stephen J. Weiss  

PROVIDER: GSE77677 | GEO | 2016-10-05

SECONDARY ACCESSION(S): PRJNA311199

REPOSITORIES: GEO

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Publications

Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.

Feinberg Tamar Y TY   Rowe R Grant RG   Saunders Thomas L TL   Weiss Stephen J SJ  

Development (Cambridge, England) 20160915 21


During late embryogenesis, mammary epithelial cells initiate migration programs that drive ductal invasion into the surrounding adipose-rich mesenchyme. Currently, branching morphogenesis is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases MMP14 (MT1-MMP) and MMP15 (MT2-MMP), which drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. However, the roles that these proteinases play during mammary  ...[more]

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