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Embryonic neocortical HuR-immunoprecipitated mRNAs

ABSTRACT: Forkhead-box domain (Fox) containing family members are known autism spectrum associated genes. Here we show that, within the developing neocortex, the distinct phospho-states of a single RNA-binding protein, Hu antigen R, dictate mRNA translation and are sufficient to define distinct Foxp-characterized subpopulations of neocortical projection neurons. This demonstrates the importance of HuR phospho-states within the framework of the developing brain and further confirms the role of mRNA translation in autism pathogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE77712 | GEO | 2016/07/08

SECONDARY ACCESSION(S): PRJNA311269

REPOSITORIES: GEO

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Temporally defined neocortical translation and polysome assembly is determined by the RNA-binding protein, Hu antigen R

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