Response to poly(I:C) in WT and GADD34ΔC/ΔC MEFs

ABSTRACT: The stress-inducible GADD34 was shown to be induced during dsRNA sensing and is a stress-inducible PP1 cofactor responsible for dephosphorylation of translation initiation factor eIF2alpha. Its activity was shown to be required for efficient cytokine production in MEFs after poly(I:C) delivery. A microarray-based mRNA transcription analysis was used to compare the transcriptional response of WT and GADD34ΔC/ΔC MEFs lipofected with poly(I:C)

ORGANISM(S): Mus musculus

PROVIDER: GSE77777 | GEO | 2017/01/16

SECONDARY ACCESSION(S): PRJNA311522

REPOSITORIES: GEO