Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer

ABSTRACT: Tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in an individual, we analyzed multiple tumors from men with disseminated prostate cancer through whole-exome sequencing, array comparative genomic hybridization (CGH) and RNA transcript profiling, and we compared the genomic diversity within and between individuals.

ORGANISM(S): Homo sapiens

PROVIDER: GSE77930 | GEO | 2016/02/16

SECONDARY ACCESSION(S): PRJNA312246

REPOSITORIES: GEO