Transcriptomics,Genomics

Dataset Information

42

The GEP of Treg subpopulations A and B and matchd T conventional


ABSTRACT: Transcriptom analysis of Treg subpopulations based on CD4,CD25,CD127,CCR4,CD45RO and CD95 expression Overall design: We have analysed sorted Treg subpopulations based on CD4,CD25,CD127,CCR4,CD45RO and CD95 expression

INSTRUMENT(S): [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]

SUBMITTER: Shahram Kordasti  

PROVIDER: GSE78004 | GEO | 2016-11-22

SECONDARY ACCESSION(S): PRJNA312345

REPOSITORIES: GEO

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Publications


Idiopathic aplastic anemia (AA) is an immune-mediated and serious form of bone marrow failure. Akin to other autoimmune diseases, we have previously shown that in AA regulatory T cells (Tregs) are reduced in number and function. The aim of this study was to further characterize Treg subpopulations in AA and investigate the potential correlation between specific Treg subsets and response to immunosuppressive therapy (IST) as well as their in vitro expandability for potential clinical use. Using m  ...[more]

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