Genomics

Dataset Information

0

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters. [ChIP-Seq]


ABSTRACT: Hypoxia inducible factor (HIF) directs an extensive transcriptional cascade that transduces numerous adaptive responses to hypoxia. Pan-genomic analyses, using chromatin immunoprecipitation and transcript profiling, have revealed large numbers of HIF-binding sites that are generally associated with hypoxia-inducible transcripts, even over long chromosomal distances. However, these studies do not define the specific targets of HIF-binding sites and do not reveal how induction of HIF affects chromatin conformation over distantly connected functional elements. To address these questions we deployed a recently developed chromosome conformation assay that enables simultaneous high-resolution analyses from multiple viewpoints. These assays defined specific long-range interactions between intergenic HIF-binding regions and one or more promoters of hypoxia-inducible genes, revealing the existence of multiple enhancer-promoter, promoter-enhancer and enhancer-enhancer interactions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE78113 | GEO | 2016/09/14

SECONDARY ACCESSION(S): PRJNA312626

REPOSITORIES: GEO

Similar Datasets

2016-09-14 | GSE78100 | GEO
2019-09-24 | GSE120524 | GEO
2019-09-24 | GSE120523 | GEO
2009-10-09 | GSE18499 | GEO
2009-06-02 | GSE16347 | GEO
2017-07-11 | GSE101063 | GEO
2017-07-11 | GSE101062 | GEO
2019-11-18 | BIOMD0000000867 | BioModels
2018-10-06 | GSE120886 | GEO
2018-10-06 | GSE120885 | GEO