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Silencing of GATA3 defines a novel stem cell like subgroup of ETP-ALL

ABSTRACT: Genome wide expression profiling was used to detect cases of adult T-ALL lacking GATA3 expression. GATA3low T-ALL exhibited enrichment of myeloid/lymphoid progenitor (MLP) and granulocyte/monocyte progenitor (GMP) genes, while T-cell specific signatures were downregulated. Among upregulated genes FLT3 was identified and mutational analyses revealed a high rate of FLT3 mutations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE78132 | GEO | 2016/02/26

SECONDARY ACCESSION(S): PRJNA313225

REPOSITORIES: GEO

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Silencing of GATA3 defines a novel stem cell like subgroup of ETP-ALL

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