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RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

ABSTRACT: RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE78143 | GEO | 2017/08/11

SECONDARY ACCESSION(S): PRJNA312769

REPOSITORIES: GEO

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Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice

Project description:We sequenced strand-specific rRNA-depleted librairies performed from total RNAs isolated from subcutaneous inguinal fat pads of three 2-week-old wild-type female mice and three 2-week-old Egr1-deficient female mice.

2017-11-23 | GSE91058 | GEO

Interaction between PPARγ and mTORC1 in the regulation of inguinal white adipose tissue transcriptome

Project description:Purpose: To investigate the involvement of mTORC1 as a mediator of the actions of the PPARγ ligand rosiglitazone in subcutaneous inguinal white adipose tissue transcriptome; Methods: Mice bearing regulatory associated protein of mTOR (Raptor) deletion and therefore mTORC1 deficiency exclusively in adipocytes (adiponectin Cre recombinase) and littermate controls were fed a high-fat diet supplemented or not with the PPARγ agonist rosiglitazone (30 mg/kg/day) for 8 weeks and evaluated for inguinal white adipose tissue transcriptome (Rnaseq); Results: 3,2425 genes had their correspondent mRNA levels altered by either adipocyte Raptor deficiency or rosiglitazone administration or their combination. Among those, 408 genes modulated by rosiglitazone required mTORC1. Conclusion: PPARγ and mTORC1 are essential partners in the regulation of a cluster of genes in inguinal white adipose tissue.

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2018-03-01 | GSE95595 | GEO

Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Project description:Here we provide scRNAseq data from the stromal vascular fraction of adult (8 weeks) and adolescent (2 weeks) murine inguinal subcutaneous white adipose tissue. This allows studying cellular composition and cellular heterogeneity within subcutaneous fat.

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Genes upregulated by HLX

Project description:HLX was found as a VEGF-A induced gene in HUVEC (B.Schweighofer, submitted). In order to detect genes regulated by HLX HUVEC were infected by recombinant adenovirus expressing HLX for 4, 8, 16 and 32h. RNA was isolated and subjected to microarray analysis using Affymetrix microarray. HUVEC were infected with a MOI of 40 with either HLX expressing or empty adenovirus for 4, 8, 16 or 32 hours. HUVEC without an adenovirus infection were used as control.Total RNA was isolated with Trizol according to the instructions of the manufacturer. Gene expression was analysed with Affymetrix GeneChip Human Genome U133 Plus 2.0 Arrays according to the Affymetrix protocol.

2011-02-15 | E-GEOD-13054 | biostudies-arrayexpress

Mus musculus

Project description:RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

| PRJNA312769 | ENA

Genes upregulated by HLX

2011-02-15 | GSE13054 | GEO

RNA-sequence analysis of immortalized, differentiated preadipocytes derived from inguinal subcutaneous white adipose tissue.

Project description:RNA-sequence analysis of immortalized, differentiated preadipocytes derived from inguinal subcutaneous white adipose tissue.

| PRJNA421901 | ENA

Transcriptomic profiling of subcutaneous white adipose tissue with selective ablation of Bmal1 at ambient and cold condition

Project description:Mice with beige fat-selective ablation of Bmal1 were generated by crossing Bmal1fl/fl with Prrx1-Cre transgenics. Inguinal subcutaneous adipsoe tissues were collected under ambient temperature at 220C or cold acclimations at 10oC for two weeks.

2021-08-31 | GSE183000 | GEO

Mouse interscapular brown, subscapular white and inguinal white adipose tissue

Project description:Adult mouse were kept at room temperature, RNAseq was performed for interscapular brown, subscapular white and inguinal white adipose tissue

2020-07-13 | E-MTAB-9192 | biostudies-arrayexpress

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