Gene expression data from OVA-immunized WT and Rptor-/- follicular regulatory T cells

ABSTRACT: Follicular regulatory T (Tfr) cells maintain homeostasis of humoral immunity by suppressing germinal center responses. TFR cells are differentiated from conventional regulatory T (Treg) cells, but underlying mechanisms remain largely unknown. We did microarray experiments to elucidate the transcriptome changes due to Rptor deficiency in Tfr cells. These data clearly demonstrate that Tfr-associated genes were down-regulated in Rptor-null Tfr cells, indicating that Raptor regulate Tfr generation by strengthening Tfr signatures.

ORGANISM(S): Mus musculus

PROVIDER: GSE78190 | GEO | 2017/02/20

SECONDARY ACCESSION(S): PRJNA312896

REPOSITORIES: GEO