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Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction

ABSTRACT: transcriptional profile of both macrophages and endothelial end cells between three different lesion stages (uninjured control , upon macrophage arrival , and during macrophage traction).

ORGANISM(S): Danio rerio

PROVIDER: GSE78194 | GEO | 2016/02/23

SECONDARY ACCESSION(S): PRJNA312899

REPOSITORIES: GEO

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Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction

Project description:transcriptional profile of both macrophages and endothelial end cells between three different lesion stages (uninjured control , upon macrophage arrival , and during macrophage traction). Examination of gene expression different in 2 cell types.

2016-02-23 | E-GEOD-78194 | biostudies-arrayexpress

scRNAseq of mpeg1.1+ cells from lesioned and unlesioned zebrafish larvae spinal cord

Project description:To analyse lesion-induced gene regulation in macrophage and microglia at single cell resolution, we performed single cell RNAseq on FACS-isolated mpeg1.1:GFP cells from the spinal cord at 24 hours post-lesion (hpl) after spinal injury at 3 days post-fertilisation (dpf), compared to age-matched uninjured animals.

2021-05-24 | E-MTAB-10379 | biostudies-arrayexpress

scRNAseq of her4.3+ cells from lesioned and unlesioned zebrafish larvae spinal cord

Project description:To analyse lesion-induced gene regulation in progenitor cells at single cell resolution, we performed single cell RNAseq on FACS-isolated her4.3:GFP progenitor cells from the spinal cord at 24 hours post-lesion (hpl) after spinal injury at 3 days post-fertilisation (dpf), compared to age-matched uninjured animals.

2021-05-24 | E-MTAB-10390 | biostudies-arrayexpress

Skeletal muscle injury-responsive macrophage subsets in larval zebrafish

Project description:Single-cell RNA-sequencing (scRNA-seq) was applied to identify and characterise macrophage subsets that responded to larval zebrafish muscle injury. The Tg(mpeg1:mCherry) transgenic zebrafish line was utilised to isolate mCherry-expressing macrophages by FACS. Following needle-stab muscle injury of a 4 days post fertilisation (dpf) larvae, the wound site was dissected out at 1, 2, and 3 days post injury (dpi) for macrophage isolation. Macrophages isolated from 4 dpf-uninjured larvae were also included. This analysis led to the identification of 8 discrete clusters of macrophages, one of which corresponded to uninjured macrophages. The 7 wound-present macrophage subsets highlighted greater macrophage heterogeneity than previously described in an in vivo skeletal muscle injury context.

2020-12-11 | GSE162979 | GEO

Bulk RNA-seq of aorta intima resident macrophage from B6, and adventitia macrophages from ApoE-/- mice

Project description:Macrophages in atherosclerotic aorta are major population in lesion and contributes to lesion formation by becoming foam cells. To investigate in determine diversity of arterial macrophage, we extracted aorta intima resident macrophages (CD11c+ MHC II+ CD64+ macrophages from C57BL/6 mice, as well as adventitia macrophages from atherosclerotic aorta (which complement our prior submissions of foamy and non-foamy intima macrophage). Our data identify unique gene expression signatures for these different macrophage populations in the aorta.

2020-07-23 | GSE154921 | GEO

Mechanical Criterion for the Rupture of a Cell Membrane under Compression.

Project description: Not available

| S-EPMC5192693 | biostudies-literature

Elasticity and rupture of a multi-domain neural cell adhesion molecule complex.

Project description: Not available

| S-EPMC2718298 | biostudies-literature

Mus musculus

Project description:bulk RNAseq of uninjured and 18 hours post-methyl bromide lesion FACS Horizontal basal cells (HBCs)

| PRJNA358591 | ENA

Sialic acid-mediated mechanical activation of β2 adrenergic receptors by bacterial pili

Project description:Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Molecular mechanisms of receptor activation by the pathogen and of its species selectivity remained elusive. We report that β2AR activation requires two asparagine-branched glycan chains with terminally exposed N-acetyl neuraminic acid (sialic acid, Neu5Ac) residues located at a specific distance in its N34 terminus, while being independent of surrounding amino-acid residues. Meningococcus triggers receptor signaling by exerting direct and hemodynamic-promoted traction forces on β2AR glycans. Similar activation is recapitulated with beads coated with Neu5Ac-binding lectins, submitted to mechanical stimulation. This previously unknown glycan-dependent mode of allosteric mechanical activation of a G protein-coupled receptor contributes to meningococcal species selectivity, since Neu5Ac is only abundant in humans due to the loss of CMAH, the enzyme converting Neu5Ac into N-glycolyl-neuraminic acid in other mammals. It represents an additional mechanism of evolutionary adaptation of a pathogen to its host.

2019-11-12 | PXD015389 | Pride

Efficacy of traction assisted endoscopic submucosal dissection using clip and line for colorectal neoplasms: a randomized controlled trial

Project description:Interventions: Conventional ESD group Traction assisted ESD group Primary outcome(s): ESD procedure time which is measured from the start of the submucosal injection until removal of the lesion Study Design: Parallel Randomized

| 2633910 | ecrin-mdr-crc

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