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Global analysis of gene expression in REF52 cells expressing SV40 T antigens

ABSTRACT: SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell proliferation and survival by action on multiple proteins, including the tumor suppressors Rb and p53. Large T antigen also binds components of the transcription initiation complex and several transcription factors. We examine global gene expression in SV40-transformed REF52 cells. SV40 transformation alters the expression of approximately 480 cellular genes. Much of this regulation is consistent with T antigen action on the Rb-E2F pathway.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE7836 | GEO | 2009/09/01

SECONDARY ACCESSION(S): PRJNA99957

REPOSITORIES: GEO

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