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Angiogenesis study of Gd@C82(OH)22 nanoparticle

ABSTRACT: we report a novel nanomedicine (Gd@C82(OH)22 ) effectively inhibit human breast tumor growth by antiangiogenesis in vivo. To further identify which angiogenic factor(s) were affected on mRNA level, the "RT² Profiler™ PCR Array Mouse Angiogenesis (APMM-024, SuperArray Bioscience Corporation)" was used. Keywords: nanomedicine, Gd@C82(OH)22, angiogenesis, MCF-7, breast cancer

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE7861 | GEO | 2009/04/01

SECONDARY ACCESSION(S): PRJNA99999

REPOSITORIES: GEO

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Angiogenesis study of Gd@C82(OH)22 nanoparticle

Project description:we report a novel nanomedicine (Gd@C82(OH)22 ) effectively inhibit human breast tumor growth by antiangiogenesis in vivo. To further identify which angiogenic factor(s) were affected on mRNA level, the "RT² Profiler™ PCR Array Mouse Angiogenesis (APMM-024, SuperArray Bioscience Corporation)" was used. Keywords: nanomedicine, Gd@C82(OH)22, angiogenesis, MCF-7, breast cancer In the experimental group, the tumor bearing mice were administered intraperitoneally (i.p.) [Gd@C82(OH)22]n saline solution once a day at the dose of 2.5mM/kg, after the tumor tissue implantation into the animal for 7 days, continuing until the mice were sacrificed. The 0.9% saline soultion was used as control. At the end of the experiment, parts of the tumor tissue was collected, and further be analyzed by PCR-array.

2009-04-01 | E-GEOD-7861 | biostudies-arrayexpress

Angiogenesis study of Gd@C82(OH)22 nanoparticle

Project description:Angiogenesis study of Gd@C82(OH)22 nanoparticle

| PRJNA99999 | ENA

gd T-cells regulate transcriptional response to diet in the intestinal epithelium

Project description:As a site of direct encounter with the external environment, the intestine must balance nutrient uptake with barrier defense. This requires coordination between numerous cell types that engage whole tissue responses to changes in environmental variables. To investigate how nutrient uptake is regulated in the small intestine, we tested the effects of diets with different macronutrient composition on epithelial cell gene expression. We found that expression of enzymes and transporters required for digestion and absorption of carbohydrates, but not protein, was dependent on substrate availability. Surprisingly, the ‘on-demand’ induction of this machinery required gd Tcells, which regulated this program via suppression of IL-22 expression by ILC3s. We found that nutrient availability alters the tissue localization and transcriptome of gd T-cells and that transcriptional responses to diet involved cellular remodeling of the epithelial compartment. This work thus identified a novel role of intestinal gd T-cells in nutrient sensing.

2021-03-01 | GSE145857 | GEO

PBS vs. LPS stimulation of gd T cells

Project description:gd T cells recognize unprocessed or non-peptide antigens, respond rapidly to infection, and localize to mucosal surfaces. We have hypothesized that the innate functions of gd T cells may be more similar to those of cells of the myeloid lineage than to other T cells. To begin to test this assumption, we have analyzed the direct response of cultured human and peripheral blood bovine gd T cells to pathogen associated molecular patterns (PAMPs) in the absence of APCs using microarray, real time RT-PCR, proteome array, and chemotaxis assays. Our results indicate that purified gd T cells respond directly to PAMPs by increasing expression of chemokine and activation related genes. The response was distinct from that to known gd T cell antigens and different from the response of myeloid cells to PAMPs. In addition, we have analyzed the expression of a variety of PAMP receptors in gd T cells. Freshly purified bovine gd T cells responded more robustly to PAMPs than did cultured human cells and expressed measurable mRNA encoding a variety of PAMP receptors. Our results suggest that rapid response to PAMPs through the expression of PAMP receptors may be another innate role of gd T cells. Keywords: parallel sample

2005-07-20 | GSE2396 | GEO

Differential Gene Expression Profiles in Broiler Chickens with Gangrenous Dermatitis (GD)

Project description:This study utilized comparative global gene expression microarray analysis of GD-affected and clinically healthy chickens from a recent GD outbreak to glean insights into the molecular and cellular changes associated with this disease process. Two-condition experiment, GD-affected vs. Healthy chickens. Biological replicates: 2 control replicates, 2 GD-infected replicates with dye-switching.

2010-10-27 | E-GEOD-24939 | biostudies-arrayexpress

Monocyte responses to Al(OH)3 adjuvant

Project description:Monocytes, derived from three different donors, were stimulated with the vaccine adjuvant Al(OH)3 for 24 and 48 hours. Proteins were isolated and equal protein amounts were labeledusing TMT(6). We found that Al(OH)3 activates various pathways related to the innate immune response.

2018-03-27 | PXD008452 | Pride

1,25(OH)2D3 upregulated lncRNA

Project description:1,25(OH)2D3 upregulated lncRNA

| PRJNA741924 | ENA

Differential and overlapping effects of 20.23(OH)2D3 and 1,25(OH)2D3 on gene expression in human epidermal keratinocytes

Project description:Neonatal keratinocytes from African American donors of passage 2 or 3 were treated with 20,23(OH)2D3, 1,25(OH)2D3 or 0.1% ethanol (control) for 6 and 24 hours. The cells were harvested separately, RNA isolated and submitted for microarray analysis at the Molecular Resources Center at the UTHSC.

2018-07-19 | GSE117351 | GEO

Gene expression profiles of sorted fetal blood Vg9Vd2 gd T cells, nonVg9Vd2 gd T cells and ab T cells in Homo sapiens

Project description:Vg9Vd2 gd T cells, nonVg9Vd2 gd T cells and ab T cells were sorted from human fetal peripheral blood (<30 weeks of gestation) and RNA was isolated from 10,000-100,000 sorted T cells. RNA was amplified using the Ovation PicoSL WTA System (NuGen), labeled with biotin using the Encore BiotinIL Module (NuGen) and applied on Illumina HT12 bead arrays.

2015-01-08 | E-MTAB-2669 | biostudies-arrayexpress

Differential Gene Expression Profiles in Broiler Chickens with Gangrenous Dermatitis (GD)

2010-10-27 | GSE24939 | GEO

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