Proteasome degradative activity regulates CD8+ T lymphocyte metabolism and fate specification

ABSTRACT: Pre-effector and pre-memory cells resulting from the first CD8+ T cell division in vivo exhibit low and high rates of proteasome degradative activities, respectively. These proteasome-induced metabolic consequences were mediated in part by asymmetric segregation of Myc during cell division. Taken together, these results suggest proteasome activity as a regulator of CD8+ T lymphocyte metabolism and fate specification.

ORGANISM(S): Mus musculus

PROVIDER: GSE78750 | GEO | 2018/02/16

REPOSITORIES: GEO