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Gene expression profile of miniature pig as animal model for toxicity evaluation by using mRNA expression profiling.

ABSTRACT: Miniature pig is a useful animal model to clarify the vital reaction and the molecular mechanisms. However, physiclogical response of pig model to sodium azide (AZIDE) stress is not reveal. To establishment of large animal model for evaluate toxic stress, whole blood of miniature pig were assessed with genomics.

ORGANISM(S): Sus scrofa

PROVIDER: GSE78769 | GEO | 2016/03/02

SECONDARY ACCESSION(S): PRJNA313522

REPOSITORIES: GEO

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Gene expression profile of miniature pig as animal model for toxicity evaluation by using mRNA expression profiling.

Project description:Miniature pig is a useful animal model to clarify the vital reaction and the molecular mechanisms. However, physiclogical response of pig model to sodium azide (AZIDE) stress is not reveal. To establishment of large animal model for evaluate toxic stress, whole blood of miniature pig were assessed with genomics. 7 month old clawn miniature pigs were fed AZIDE feeding. AZIDE dose of 300Âµg/kg, one hundredth of LD50 was given orally to the miniature pigs. Whole blood gene expression was measured at 0h, 6h and 24h after feeding.

2016-03-02 | E-GEOD-78769 | biostudies-arrayexpress

WGBS analysis of Landrance and Wuzhishan miniature pig

Project description:Here, we performed the first whole-genome bisulfite sequencing (WGBS) of longissimus dorsi muscle (LDM) from Landrace (LR) and Wuzhishan (WZS) miniature pig during early embryonic stages (18, 21 and 28 dpc (days post coitum)).

2019-09-04 | GSE119459 | GEO

Quantitative proteomic analysis of deciduous molars in miniature pig (second repetition)

Project description:By combining isobaric tandem mass tag (TMT) labeling with liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) technology, we constructed protein regulated profiles of deciduous molar germ at embryonic days 40 and 50 ,60 in miniature pig.

2018-05-23 | PXD006174 | Pride

Evaluation of the physiology of miniature pig fed Shochu distilled water by using mRNA expression profiling.

Project description:Shochu distilled water (SDW) was used as a feedstuff for livestock. We have tried to evaluate the physiology of pig during feeding SDW using genomics. 8-9 month old clawn miniature pigs were fed standard dry feed or SDW feeding. SDW feeding composed of standard dry feed: water: SDW= 1:1:1 by the weight ratio.Whole blood gene expression in control and SDW animal was measured at 12 weeks of feeding periods.

2016-03-02 | E-GEOD-78768 | biostudies-arrayexpress

Sus scrofa domesticus breed:Bama miniature pig

Project description:Bama miniature pig transcriptome

| PRJNA302839 | ENA

Characterization of whole blood gene and while blood cell expression profiles of dietary-induced hyperlipidemia in miniature pigs

Project description:Miniature pigs are useful model animal for gene expression studies on dietary-induced hyperlipidemia, because they have similar digestive physiology to human. Two typical dietary components were used for dietary-induced hyperlipidemia miniature pig models. One is a high-fat and high-cholesterol diet (HFCD) containing 15% lard and 2% cholesterol, the other is a high-fat, high-cholesterol and high-sucrose diet (HFCSD) containing 15% lard, 2% cholesterol and 37% sucrose. Whole blood gene expression in HFCD, HFCSD and control male miniature pigs was measured at 10, 19 and 27 weeks of feeding periods.M-cM-^@M-^@White blood cell gene expression in HFCD, HFCSD and control male miniature pigs was measured at 27 weeks of feeding period.

2012-04-24 | E-GEOD-32616 | biostudies-arrayexpress

Characterization of whole blood gene and while blood cell expression profiles of dietary-induced hyperlipidemia in miniature pigs

2012-04-25 | GSE32616 | GEO

Sus scrofa breed:Guizhou miniature pig

Project description:Sus scrofa breed:Guizhou miniature pig Genome sequencing

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Expression data from early diphyodont morphogenesis in minature pig

Project description:The miniature pig is diphyodont, making it a valuable alternative model for understanding human tooth development and replacement. However, little is known about gene expression and function during swine odontogenesis. The goal of this study is to undertake the survey of differential gene expression profiling with Affymetrix Porcine GeneChip and functional network analysis during morphogenesis of diphyodont dentition in miniature pigs. The identification of genes related to diphyodont development should lead to a better understanding of morphogenetic patterns and the mechanisms of diphyodont replacement in large animal models and humans. The staged miniature pig embryos and fetuses were obtained by cesarean section at E40, E50, and E60. The last deciduous molar germs, including the dental lamina in mandibles from the same litter were isolated and pooled. The gestational age of embryos used in our study just cover 3 characteristic stages: Dm3 in cap stage without secondary dental lamina (E40); Dm3 in bell stage with secondary dental lamina initiation (E50); Dm3 in secretory stage without evidence of morphological changes in the secondary dental lamina.

2014-12-23 | E-GEOD-53182 | biostudies-arrayexpress

Expression data from early diphyodont morphogenesis in minature pig

2014-12-23 | GSE53182 | GEO

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