Expression data from human bronchial epithelial cells (treatment with IL-4)

ABSTRACT: Goblet cell hyperplasia (GCH) is a feature of respiratory diseases characterized by mucus hypersecretion. GCH is driven by Th2 cytokines such as IL-4. To investigate the gene expression changes associated with GCH, we treated human bronchial epithelial cells with IL-4. By microarray analysis and functional studies, we found that IL-4 promotes a profound change that results in enhanced bicarbonate secretion. This change may be required to support mucus release.

ORGANISM(S): Homo sapiens

PROVIDER: GSE78914 | GEO | 2016/11/09

SECONDARY ACCESSION(S): PRJNA314344

REPOSITORIES: GEO