Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Pantherophis guttatus

PROVIDER: GSE79048 | GEO | 2016/11/05

SECONDARY ACCESSION(S): PRJNA314796

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan (ChIP-seq)

Project description:While the vertebrate body plan is highly conserved amongst all species of this taxon, extreme variations thereof can be documented in snakes, which display both an absence of limbs and an unusually elongated trunk. As Hox genes are strong candidates both for the making and the evolution of this body plan, their comparative study in such a morphologically diverged group is informative regarding their potential causative importance in these processes. In this work we use an interspecies comparative approach where different aspects of regulation at the HoxD locus are investigated. We find that although spatial collinearity and associated epigenetic mark dynamics are conserved in the corn snake, other regulatory modalities have been largely restructured. A BAC transgenic approach indeed revealed that, while the majority of mesodermal enhancers in vertebrates appear to be mostly located outside of the cluster, the corn snake contains most mesodermal trunk enhancers within the HoxD cluster. We also find that, despite the absence of limbs and an altered Hoxd gene regulation in external genitalia, the bimodal chromatin structure at the corn snake HoxD locus is maintained. The analysis of particular enhancer sequences initially defined in the mouse and further isolated at the snake orthologous locus showed differences in their specificities for the limb and genital bud expression. Of particular interest, a snake counterpart of a mouse limb-only enhancer sequence evolved into a genital-only enhancer. Such a regulatory exaptation suggests that enhancer versatility may have been an important factor to accompany the transition towards the snake body plan. These results show that vertebrate morphological evolution is likely to have been associated with extensive reorganization at the HoxD regulatory landscapes while respecting a very conserved general regulatory framework.

2016-11-05 | GSE79047 | GEO

Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan (4C-seq)

2016-11-05 | GSE79045 | GEO

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan.

Project description: Not available

| S-EPMC4969037 | biostudies-other

Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan

Project description:Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan

| PRJNA314796 | ENA

Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan (ChIP-seq)

Project description:Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan (ChIP-seq)

| PRJNA314797 | ENA

Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan (4C-seq)

Project description:Reorganization of HoxD regulatory landscapes during the evolution of a snake-like body plan (4C-seq)

| PRJNA314793 | ENA

New skulls and skeletons of the Cretaceous legged snake Najash, and the evolution of the modern snake body plan.

Project description: Not available

| S-EPMC6867888 | biostudies-literature

Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-11-21 | E-GEOD-62269 | biostudies-arrayexpress

sponge body plan

Project description:In order to compare sponge and eumetazoan (higher animal) body plans, we identified and studied expression of a broad range of eumetazoan developmental regulatory genes in Sycon ciliatum (Calcispongiae). In this species, embryonic development is semi-synchronous within a population, synchronous within individuals, and oocytes and embryos occupy a significant fraction of the volume of the sponges during the reproductive period. RNASeq libraries representing non-reproductive (somatic) tissue slices along the body axis, as well as oocytes, embryos and free swimming larvae were generated from material obtained by sampling throughout the life cycle.

2014-05-01 | E-MTAB-2430 | biostudies-arrayexpress

sponge body plan

Project description:sponge body plan

| PRJEB5970 | ENA