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AP-1 and TEAD4 co-operatively promote the vascular program during hemangioblast specification

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE79323 | GEO | 2016/10/21

SECONDARY ACCESSION(S): PRJNA315459

REPOSITORIES: GEO

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AP-1 and TEAD4 co-operatively promote the vascular program during hemangioblast specification [expression]

Project description:Embryonic blood cell development occurs via well-defined developmental stages which are recapitulated in vitro by differentiation of embryonic stem cells. This process is tightly regulated by the interaction of tissue- specific and ubiquitous transcription factors with the chromatin landscape in response to outside signals. We previously identified binding motifs for the commonly expressed AP-1 transcription factor family in open chromatin regions specific for early stages of blood specification and thus aimed to study the role of AP-1 for hemangioblast differentiation. Here we show that FOS and JUN together bind to and activate a core set of vascular genes in the hemogenic endothelium and that upon global inhibition of AP-1 by expression of a dominant negative FOS peptide the balance between endothelial and hematopoietic fate is shifted towards blood. Moreover, we demonstrate that in the hemogenic endothelium AP-1 is required for de novo binding of TEAD4, a transcription factor connected to Hippo signaling, to vascular genes. Notably, after the endothelial-to-hematopoietic transition TEAD4 binding is no longer persisting. These findings provide novel mechanistic insights into vascular and hematopoietic development.

2016-10-21 | GSE79322 | GEO

AP-1 and TEAD4 co-operatively promote the vascular program during hemangioblast specification [DNase-Seq]

2016-10-21 | GSE79321 | GEO

AP-1 and TEAD4 co-operatively promote the vascular program during hemangioblast specification [ChIP-Seq]

2016-10-21 | GSE79320 | GEO

AP-1 and TEAD4 co-operatively promote the vascular program during hemangioblast specification

Project description:AP-1 and TEAD4 co-operatively promote the vascular program during hemangioblast specification

| PRJNA315459 | ENA

Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate.

Project description: Not available

| S-EPMC5201045 | biostudies-literature

VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-16 | GSE193621 | GEO

Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast.

Project description: Not available

| S-EPMC3039875 | biostudies-literature

Co-Stimulation–Induced AP-1 Activity is Required for Chromatin Opening During T Cell Activation.

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-10-16 | GSE116698 | GEO

BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development.

Project description: Not available

| S-EPMC3585661 | biostudies-literature

Gata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development

Project description:The first lineage decisions during mouse development lead to establishment of embryonic and extraembryonic tissues. The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4 and promoting trophoblast fate at the blastocyst stage. Here we show that the transcription factor Gata3 is coexpressed with Cdx2 in the blastocyst and that overexpression of Gata3 in embryonic stem cells is sufficient to induce expression of trophoblast genes. Gata3 expression in the blastocyst does not depend on Cdx2, nor do Gata3 overexpressing cell lines require Cdx2 for expression of a subset of trophoblast genes. In the embryo, expression of Gata3, like Cdx2, depends on Tead4, and expression of both factors becomes restricted to nascent trophoblast by an Oct4-independent mechanism. These observations place Tead4 at the top of a trophoblast hierarchy, with Gata3 and Cdx2 acting downstream to induce expression of common and independent targets in this lineage. This SuperSeries is composed of the SubSeries listed below.

2010-02-01 | GSE12999 | GEO

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