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Genome-wide mapping of H4Ac in Legionella pneumophila-infected human macrophages

ABSTRACT: In this study we infected human blood-derived macrophages with L. pneumophila and used immunoprecipitation followed by sequencing (ChIP-Seq) to screen gene promoters for the activating histone 4 acetylation mark. We found about 500 genes with induced acetylation upon infection, including several pro-inflamatory and inflamatory factors and non-coding RNAs. In particular, we assess the functional consequences of tumor necrosis factor alpha-induced protein 2 (TNFAIP2), a factor not yet characterized in the pathology of L.pneumophila, on bacterial replication.

ORGANISM(S): Homo sapiens

PROVIDER: GSE79390 | GEO | 2016/04/18

SECONDARY ACCESSION(S): PRJNA315682

REPOSITORIES: GEO

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