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Analysis of atnuc-l1 mutant line-Characterization of a nucleolin gene in Arabidopsis thaliana mutant line

ABSTRACT: rs05-07_nucleolin - analysis of atnuc-l1 mutant line - To establish if nucleolin plays a role in controlling gene expression of genes involved in ribosome biogenesis - transcriptome analysis of the Atnuc-L1 mutant line Keywords: gene knock out

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE7943 | GEO | 2007/05/31

SECONDARY ACCESSION(S): PRJNA100117

REPOSITORIES: GEO

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Arabidopsis thaliana

Project description:analysis of atnuc-l1 mutant line-Characterization of a nucleolin gene in Arabidopsis thaliana mutant line

| PRJNA100117 | ENA

Genome-wide analysis of gene expression regulated by nucleolin in mouse embryonic stem cells

Project description:To further explore the function and underlying mechanism of nucleolin in embryonic stem cells (ESCs), we compared the transcription profile of tetracycline (Tc)-inducible EGFP (as a control) or nucleolin siRNA expression-stable ESCs cultured with or without Tc for 3 days, and identified distinct classes of up- and down-regulated genes by nucleolin in mouse ESCs. Total RNA obtained from CGR8 ES cells stably integrated with Tc-inducible siRNA EGFP, nucleoin-1 or nucleolin-2 cultured with or without Tc for 3 days, and then hybridized to Illumina Sentrix Mouse-6 v2.0 BeadChips. Three replicates each condition.

2011-10-19 | E-GEOD-23993 | biostudies-arrayexpress

Identification of nucleolin-targeted RNA transcripts

Project description:Although Rrp6 contains a helicase and RNase D domain at the C-terminus, it is not involved in stable RNA interactions. We thus hypothesized that mRrp6-mediated nucleolar inflammatory RNA degradation may depend on the pre-mRNA substrate that is delivered to the mRrp6-exosome complex by nucleolin as a guide factor. To demonstrate this possibility, we examined nucleoplasmic RNAs which were bound to nucleolin through RNA-IP-sequencing at the late time points of LPS stimulation.

2021-02-28 | GSE95528 | GEO

Gene expression of nucleolin or TRA2B4-silencing HCT116 cells

Project description:TRA2β4 is transcribed from the human transformer 2β(TRA2B) gene and overexpressed in colon cancer cells. Nucleolin is one of RNA-binding proteins to regulate cell survival and proliferation. In this study, TRA2β4 and Nucleolin levels were reduced in colon cancer HCT116 cells and gene expression levels were measured using microarray analysis.

2018-04-06 | GSE112758 | GEO

Genome-wide analysis of gene expression regulated by nucleolin in mouse embryonic stem cells

2011-10-20 | GSE23993 | GEO

iCLIP Analysis of WT, phospho-defective, and phospho-mimicking mutants of mouse Nucleolin in iKras PDAC cells

Project description:This experiment aimed to identify Nucleolin (Ncl) binding sites on a transcriptome-wide scale, by performing iCLIP in mouse iKras PDAC cells (Ying et al., 2012) transiently transfected with a mammalian expression construct encoding a wild-type (WT) myc-Ncl, a phospho-defective mutant in which S28, S34, S40, and S41 residues were mutated to A, or a phospho-mimicking mutant with these residues mutated to D. Cells transfected with an empty vector (myc-pRK5-DEST) were used as controls in the experiment.

2023-03-01 | E-MTAB-12481 | biostudies-arrayexpress

Analysis of RNA localization in nucleolin deficient axons

Project description:We previously showed that the RNA binding protein Nucleolin is localized to axons of DRG sensory neurons by interaction with the molecular motor Kinesin-1 (Kif5A) and subsequently localizes importin beta1 mRNA there (Perry et al., 2016). In this work, we created a mouse with a heterozygous deletion of the domain in nucleolin responsible for the Kif5A interaction and showed that nucelolin protein levels are reduced in the axons of dorsal root ganglia neurons in this mouse model. The goal of this study was to identify RNAs who's axonal localization is affected by this perturbation.

2021-07-23 | GSE142096 | GEO

AhR mutant vs N2 wild-type C.elegans, in L1 larval stage

Project description:Expression profiles of AhR mutant vs N2 wild-type C.elegans, in L1 larval stage compared by using 23232 feature WUSTL microarray

2009-12-19 | GSE16036 | GEO

Transcription profiling of Arabidopsis HSI2 and HSI2-L1 double mutant

Project description:The effect of HSI2 and HSI2-L1 double mutant on plant gene expression.

2007-02-02 | E-MEXP-542 | biostudies-arrayexpress

Nucleolin is a cell surface receptor of C1QTNF4

Project description:C1QTNF4 is a secreted protein that is structurally unique within the C1QTNF family, a family of proteins that have structural homology with both complement C1q and the tumor necrosis factor superfamily. The role of C1QTNF4 in immunity and inflammation remains poorly defined and a cell surface receptor has yet to be identified. Here we performed co-immunoprecipitation with subsequent mass spectrometric analysis in order to identify a cell surface receptor of C1QTNF4. We report identification of nucleolin as a cell surface binding partner of C1QTNF4. Nucleolin may serve as a docking molecule for C1QTNF4 and act in a context-dependent manner through co-receptors. Having identified nucleolin as a cell surface receptor is a further step to understanding C1QTNF4’s function in the healthy immune system.

2021-03-21 | PXD023088 | Pride

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