Transcriptomics,Genomics

Dataset Information

31

Expression data from B-cell precursor acute lymphoblastic leukemia


ABSTRACT: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous disease that can be subdivided according to primary recurrent genetic abnormalities that are strongly associated with characteristic biological and clinical features. The detection of these abnormalities can facilitate diagnosis, risk stratification, and targeted therapy. We identified an unexpectedly high incidence of fusion genes involving ZNF384 genes, including TCF3-ZNF384, EP300-ZNF384, and CREBBP-ZNF384, in BCP-ALL of our cohort. We therefore used microarrays to evaluate the gene-expression characteristics of BCP-ALL harboring ZNF384-related fusion genes and compared with those of BCP-ALL with other types of conventional genetic abnormality. Overall design: BCP-ALL samples with various genetic abnormalities were selected for RNA extraction and hybridization on Affymetrix microarrays. In addition to BCP-ALL harboring ZNF384-related fusion genes, including TCF3-ZNF384 (10 cases), EP300-ZNF384 (5 cases), and CREBBP-ZNF384 (2 cases), BCP-ALL with conventional genetic abnormalities, such as BCR-ABL1 (19 cases), ETV6-RUNX1 (70 cases), high hyperdiploid (90 cases), MLL-AF4 (13 cases), and TCF3-PBX1 (19 cases), were included. As a control, non-leukemic B-cell precursor samples (3 cases) were also selected.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: NOBUTAKA KIYOKAWA  

PROVIDER: GSE79533 | GEO | 2017-03-21

SECONDARY ACCESSION(S): PRJNA316107

REPOSITORIES: GEO

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Publications

ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype.

Hirabayashi Shinsuke S   Ohki Kentaro K   Nakabayashi Kazuhiko K   Ichikawa Hitoshi H   Momozawa Yukihide Y   Okamura Kohji K   Yaguchi Akinori A   Terada Kazuki K   Saito Yuya Y   Yoshimi Ai A   Ogata-Kawata Hiroko H   Sakamoto Hiromi H   Kato Motohiro M   Fujimura Junya J   Hino Moeko M   Kinoshita Akitoshi A   Kakuda Harumi H   Kurosawa Hidemitsu H   Kato Keisuke K   Kajiwara Ryosuke R   Moriwaki Koichi K   Morimoto Tsuyoshi T   Nakamura Kozue K   Noguchi Yasushi Y   Osumi Tomoo T   Sakashita Kazuo K   Takita Junko J   Yuza Yuki Y   Matsuda Koich K   Yoshida Teruhiko T   Matsumoto Kenji K   Hata Kenichiro K   Kubo Michiaki M   Matsubara Yoichi Y   Fukushima Takashi T   Koh Katsuyoshi K   Manabe Atsushi A   Ohara Akira A   Kiyokawa Nobutaka N  

Haematologica 20160915 1


Fusion genes involving ZNF384 have recently been identified in B-cell precursor acute lymphoblastic leukemia, and 7 fusion partners have been reported. We further characterized this type of fusion gene by whole transcriptome sequencing and/or polymerase chain reaction. In addition to previously reported genes, we identified BMP2K as a novel fusion partner for ZNF384 Including the EP300-ZNF384 that we reported recently, the total frequency of ZNF384-related fusion genes was 4.1% in 291 B-cell pre  ...[more]

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