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Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells [ATAC-seq]

ABSTRACT: To identify the open chromatin cis-regulatory elements present in uninfected and T. gondii (Type I-RH) infected HFFs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE79609 | GEO | 2017/03/08

SECONDARY ACCESSION(S): PRJNA316437

REPOSITORIES: GEO

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Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells [RNA-seq]

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2017-03-08 | GSE79608 | GEO

Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells [HELP-GT]

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Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells [HELP-tagging]

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MicroRNA expression profile of porcine alveolar macrophages infected with Toxoplasma gondii

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2013-08-20 | E-GEOD-44189 | biostudies-arrayexpress

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2011-01-10 | E-GEOD-25476 | biostudies-arrayexpress

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Genome-wide analysis of gene expression response upon infection with Toxoplasma gondii

Project description:The in vitro effect of infection with different strains of Toxoplasma gondii was tested 24 hours after infection of Human Foreskin Fibroblasts (HFF) The strains tested include RH, VEG, and transgenic strains of RH overexpressing ROP38 or ROP21 Total RNA of Toxoplasma gondii infected HFF cell was compared to uninfected cells

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Host gene expression response to Toxoplasma gondii infection is not different between RH?ku80 and RH?ku80?rop5 parasites.

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LC-MS of interacting partners Toxoplasma gondii GRA57

Project description:We identified GRA57 as a Toxoplasma gondii secreted effector required for parasite survival of interferon gamma in HFFs. To identify interaction partners of GRA57 during infection of HFFs, which could indicate how GRA57 functions to protect the parasite, we performed co-immunoprecipitation (IP) experiments with an endogenously tagged RHGRA57-HA strain.To enable detection of protein-protein interactions specific to activated cells, HFFs were pre-stimulated before infection with 2.5 U/ml IFN for 6 h, which we found was sufficient to induce IFN responses while retaining host cell viability. HFFs were infected for 24 h with either RH∆Ku80 or RHGRA57-HA parasites prior to lysis. GRA57-HA was immunoprecipitated from lysates, then co-immunoprecipitated proteins were identified by liquid chromatography (LC)-tandem mass spectrometry (MS/MS).

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