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Bisulfite-Seq and RNA-seq profiling of Arabidopsis aneuploids

ABSTRACT: Aneuploidy refers to gains and/or losses of individual chromosomes from the normal chromosome set. The resulting gene dosage imbalance usually has a deleterious effect on the phenotype, as illustrated in humans by Down Syndrome (trisomy 21) and solid tumor cells, which are typically highly aneuploid. Aneuploidy has been studied for many years in plants and has been a factor contributing to plant chromosome evolution. Nevertheless, there is still relatively little information about how chromosome numerical imbalances affect the molecular constitution of cells and confer altered phenotypes. To investigate these questions we have performed comparative transcriptome (RNA-seq) and methylome (bisulfite-seq) analyses on trisomics (2n+1) of all five chromosomes of Arabidopsis thaliana as well as matched diploids, triploid and tetraploids.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE79676 | GEO | 2018/06/20

REPOSITORIES: GEO

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Transient genomic instability drives tumorigenesis through accelerated clonal evolution

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