Transcriptomics

Dataset Information

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Investigation of Bach2 function by regulating inflammatory response and heme-iron homeostasis of bone marrow macrophage.


ABSTRACT: Macrophages are central in regulating iron homeostasis. Transcription repressor Bach2 regulates by heme. Here we investigated the relationship between heme-regulated Bach2 and macrophage in bone marrow. We identified RFP-positive and negative macrophage were in bone marrow. We found that RFP-positive macrophage related with iron-heme homeostasis maintenance and RPF-negative population related with immune response. In RFP positive macrophage, we also found the lysosomal heme transporter hrg-1 was Bach2 direct target gene. Our results suggest that the function of the bone marrow macrophage alters according to expression of Bach2.

ORGANISM(S): Mus musculus

PROVIDER: GSE79697 | GEO | 2018/09/26

REPOSITORIES: GEO

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