Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)
SUBMITTER: Sarah J Hainer
PROVIDER: GSE79770 | GEO | 2016-11-15
SECONDARY ACCESSION(S): PRJNA316979
REPOSITORIES: GEO
Hainer Sarah J SJ McCannell Kurtis N KN Yu Jun J Ee Ly-Sha LS Zhu Lihua J LJ Rando Oliver J OJ Fazzio Thomas G TG
eLife 20161116
Cytosine methylation is an epigenetic and regulatory mark that functions in part through recruitment of chromatin remodeling complexes containing methyl-CpG binding domain (MBD) proteins. Two MBD proteins, Mbd2 and Mbd3, were previously shown to bind methylated or hydroxymethylated DNA, respectively; however, both of these findings have been disputed. Here, we investigated this controversy using experimental approaches and re-analysis of published data and find no evidence for methylation-indepe ...[more]