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Genome-wide analysis of gene expression in influenza A infected human macrophages treated with VX-787

ABSTRACT: Analysis of gene expression in macrophages infected with influenza A virus or Mock and treated with the VX-787 to investigate the effects VX-787 have on transcriptional response in human macrophages.

ORGANISM(S): Homo sapiens

PROVIDER: GSE79854 | GEO | 2016/04/03

SECONDARY ACCESSION(S): PRJNA317228

REPOSITORIES: GEO

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Genome-wide analysis of gene expression in influenza A infected human macrophages treated with VX-787

Project description:Analysis of gene expression in macrophages infected with influenza A virus or Mock and treated with the VX-787 to investigate the effects VX-787 have on transcriptional response in human macrophages. Human macrophages were infected with influenza A/WSN/1933(H1N1) or A/Udorn/307/72(H3N2) viruses, or non-infected (Mock). 10nM VX-787 was treated to WSN, Udorn or Mock infected cells, repectively.

2016-04-03 | E-GEOD-79854 | biostudies-arrayexpress

Expression data of influenza A infected human macrophages

2009-10-31 | GSE18816 | GEO

Expression data of influenza A infected human macrophages

Project description:Human disease caused by highly pathogenic avian influenza (HPAI) H5N1 can lead to a rapidly progressive viral pneumonia leading to acute respiratory distress syndrome. There is increasing evidence suggests a role for virus-induced cytokine dysregulation in contributing to the pathogenesis of human H5N1 disease. The key target cells for the virus in the lung are the alveolar epithelium and alveolar macrophages, and previous data has shown that compared to seasonal human influenza viruses, equivalent infecting doses of H5N1 viruses markedly up-regulate pro-inflammatory cytokines in both primary cell types in vitro. The dysregulation of H5N1-induced host responses is therefore important for understanding the viral pathogenesis. We used microarrays to analyze and compare the gene expression profiles in primary human macrophages after influenza A virus infection. Peripheral-blood leucocytes were separated from buffy coats of three healthy blood donors and cells were differentiated for 14 days before use. Differentiated macrophages were infected with H1N1 and H5N1 at a multiplicity of infection (MOI) of two. Total RNA was extracted from cells after 1, 3, and 6h post-infection, and gene expression profiling was performed using an Affymetrix Human Gene 1.0 ST microarray platform.

2009-10-31 | E-GEOD-18816 | biostudies-arrayexpress

Gene Expression Data from Influenza A Virus-Infected and Mock-infected Mouse Eosinophils

Project description:Eosinophils are terminally differentiated granulocytes that recently have been shown to become infected with Influenza A Virus (IAV). Here, we investigate transcriptional changes that occur to bone marrow-derived eosinophils following exposure to IAV. Global changes in the transcriptome of bone marrow derived mouse eosiniphils were assessed following mock- and Influenza A virus-infection using Affymetrix mouse gene 2.0 ST microarrays.

2020-05-01 | GSE140580 | GEO

FluOMICS - Metabolomics analysis of mouse lungs infected with H1N1 influenza virus

Project description:Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/California/04/09 (H1N1) virus, mock infected with PBS, or untreated.

2017-12-06 | MSV000081785 | MassIVE

Genome-wide analysis of gene expression in human macrophages in response to infection with recombinant A/WSN/33 influenza A viruses expressing wild type NS1 protein or its mutant R38A, K41A. [macrophages]

Project description:Analysis of gene expression in human macrophages infected with influenza A viruses expressing wild type NS1 protein or its mutant R38A, K41A. The hypothesis tested was that R38 and K41 residues within viral NS1 protein are essential fro transctiptional control of cellluar gene expression. Cells were infected with influenza A/WSN/33 viruses expressing wild type NS1 protein (WT), its R38A, K41A mutant (RK/AA) or non-infected (Mock) Total RNA isolated from macrophages after 10 hours of infection with wild type or mutant influenza A virus (multiplicity of infection = 1)

2015-02-07 | E-GEOD-65702 | biostudies-arrayexpress

FluOMICS - Metabolomics analysis of mouse lungs infected with H5N1 (HALo) influenza virus

Project description:Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/Vietnam/1203/04 (H5N1) HALo virus, mock infected with PBS, or untreated.

2017-12-06 | MSV000081786 | MassIVE

Porcine macrophages: ASFV-infected vs. mock-infected

Project description:Transcriptional profiling of porcine macrophages infected with Afraican swine fever virus (ASFV) infected cells and mock infection was conducted in this experiment.

2019-09-30 | GSE132905 | GEO

Expression data from PBMCs infected with influenza A virus and treated with/without Itaconate

Project description:Analysis of gene expression in human PBMCs infected with influenza A virus or Mock and treated with Itaconic acid, Dimethyl itaconate or 4-Octyl itaconate to investigate the effects itaconate have on transcriptional response in human PBMCs. We particularly looked at anti-inflammatory effects of itaconate in inflammation followed by Influenza A virus infection.

2021-10-31 | GSE162210 | GEO

FluOMICS - Metabolomics analysis of HTBE cells infected with H1N1 influenza virus

Project description:Metabolomics analysis of human tracheobronchial epithelial (HTBE) cells was conducted at multiple time points in response to infection with influenza A/California/04/09 (H1N1) virus or mock infection.

2017-12-06 | MSV000081782 | MassIVE

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