Rapid and efficient generation of myelinating oligodendrocytes from human induced pluripotent stem cells using a combination of three transcription factors [hiPSC]

ABSTRACT: We demonstrate that the induction of three transcription factors (SOX10, OLIG2, NKX6.2) in hiPSC-derived neural progenitor cells (hiPSC-NPC) is sufficient to rapidly generate O4+ oligodendrocytes with an efficiency of 60 to 70% within 28 days.

ORGANISM(S): Homo sapiens

PROVIDER: GSE79912 | GEO | 2017/03/06

SECONDARY ACCESSION(S): PRJNA317361

REPOSITORIES: GEO