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Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE80132 | GEO | 2016/07/11

SECONDARY ACCESSION(S): PRJNA318003

REPOSITORIES: GEO

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Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.

Project description: Not available

| S-EPMC5193222 | biostudies-literature

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation (ChIP-Seq)

Project description:The host innate immune response is the first line of defense against pathogens and is orchestrated by the concerted expression of genes induced by microbial stimuli. Deregulated expression of these genes is linked to the initiation and progression of numerous diseases associated with exacerbated inflammation. Here, we identify Topoisomerase 1 (Top1) as a critical positive regulator of RNA polymerase II (RNAPII) transcriptional activity at pathogen-induced genes. Notably, depletion or chemical inhibition of Top1 suppresses the host response against replicating Influenza and Ebola viruses as well as bacterial products. As a result, therapeutic pharmacological inhibition of Top1 protects mice from death in experimental models of chemical- and pathogen-induced lethal inflammation. Our results indicate that Top1 inhibition could be used as therapy against life threatening infections characterized by an acutely exacerbated immune response.

2016-07-11 | GSE80129 | GEO

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation (RNA-Seq)

2016-07-11 | GSE80131 | GEO

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

Project description:Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

| PRJNA318003 | ENA

Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-08-30 | E-GEOD-43900 | biostudies-arrayexpress

Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-08-30 | GSE43900 | GEO