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Post-transcriptional regulation by the let-7 microRNA and the TRIM-NHL protein LIN41

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE80159 | GEO | 2017/07/17

SECONDARY ACCESSION(S): PRJNA318055

REPOSITORIES: GEO

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Post-transcriptional regulation by the let-7 microRNA and the TRIM-NHL protein LIN41 [Ribosome footprinting]

Project description:We perform RNA sequencing and ribosome profiling time course experiments to examine the effect of fully dysregulating all let-7 targets (in let-7(n2853) animals), partially dysregulating only LIN41 (in lin-41(xe11) animals) or fully dysregulating all let-7 targets while partially dysregulating LIN41 in lin-41(xe11); let-7(n2853) double mutant animals. We conclude that effects on gene expression in let-7 mutant animals are largely and quantitatively explained by dysregulation of LIN41 as its primary target. Furthermore, we identify direct LIN41 target genes regulated on the level of translation or mRNA abundance.

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Post-transcriptional regulation by the let-7 microRNA and the TRIM-NHL protein LIN41 [RNA-seq]

2017-07-17 | GSE80157 | GEO

Post-transcriptional regulation by the let-7 microRNA and the TRIM-NHL protein LIN41

Project description:Post-transcriptional regulation by the let-7 microRNA and the TRIM-NHL protein LIN41

| PRJNA318055 | ENA