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Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

OTHER RELATED OMICS DATASETS IN: PRJNA318240PRJNA318238PRJNA318239

ORGANISM(S): Homo sapiens

PROVIDER: GSE80177 | GEO | 2016/09/14

SECONDARY ACCESSION(S): PRJNA318238

REPOSITORIES: GEO

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Similar Datasets

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference.

Project description: Not available

| S-EPMC4967941 | biostudies-literature

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference [MeDIP-Seq]

Project description:Results provide the animal proof of concept that inhibition of DNA methylation can sensitize solid tumors to antibodies mediating tumor cell apoptosis.

2016-09-14 | GSE80175 | GEO

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference [RNA-Seq]

Project description:Results provide the animal proof of concept that inhibition of DNA methylation can sensitize solid tumors to antibodies mediating tumor cell apoptosis.

2016-09-14 | GSE80176 | GEO

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference

Project description:Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference

| PRJNA318238 | ENA

Breast tumor DNA methylation

Project description:Using primary breast tumors from 162 women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured CpG loci associated with cancer-related genes 162 tumor specimens from the initial diagnostic biopsy were obtained from the KPNC tumor biorepository for methylation analysis. All tumor specimens were from patients who did not receive neoadjuvant chemotherapy.

2010-07-29 | GSE22290 | GEO

Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer.

Project description: Not available

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Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition.

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MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade.

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Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation.

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DNA methylation of estrogen regulated enhancers defines endocrine sensitivity in breast cancer

Project description:Expression of estrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy as part of their adjuvant care, but does not guarantee patient response. However, the molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly understood. Here, we characterize the DNA methylome of endocrine sensitivity and demonstrate the potential impact of differential DNA methylation on endocrine response in breast cancer. We show that DNA hypermethylation occurs predominantly at estrogen-responsive enhancers and is associated with reduced ESR1 binding and decreased gene expression of key regulators of ESR1-activity; thus providing a novel mechanism by which endocrine response is abated in ESR1-positive breast cancers. Conversely, we delineate that ESR1-responsive enhancer hypomethylation is critical in transition from normal mammary epithelial cells to endocrine responsive ESR1-positive cancer. Cumulatively these novel insights highlight the potential of ESR1-responsive enhancer methylation to both predict ESR1-positive disease and stratify ESR1-positive breast cancer patients as responders to endocrine therapy.

2015-07-01 | GSE69118 | GEO

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