Transcriptomics,Genomics

Dataset Information

15

Expression data from human donor lung biopsies


ABSTRACT: Expression profile of human donor lungs that have developed primary graft dysfunction (PGD) after lung transplantation and those that have not. In this study, we attempt to further our understanding of PGD by observing the changes in gene expression across donor lungs that developed PGD versus those that did not. Keywords: stress response Overall design: The 50 donor lung samples were divided into two groups - those that developed PGD after transplantation (PGD positive) and those that did not (PGD negative). PGD was defined as T0 Grade III dysfunction according to International Society for Heart and Lung Transplantation criteria, that is, a ratio (referred to as the P/F ratio) of partial pressure of arterial oxygen (PaO2) to fraction of inspired oxygen (FiO2) less than 200 in the first arterial blood gas in the intensive care unit after transplantation (generally 4-6 hours after actual reperfusion).

INSTRUMENT(S): Affymetrix GeneChip Human Genome U133A 2.0 Array [CDF: Hs133Av2_Hs_REFSEQ_8]

SUBMITTER: Monika Ray   

PROVIDER: GSE8021 | GEO | 2007-06-06

SECONDARY ACCESSION(S): PRJNA100823

REPOSITORIES: GEO

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Publications

Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation.

Ray M   Dharmarajan S   Freudenberg J   Zhang W   Patterson GA  

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20071001 10


Lung transplantation is the treatment of choice for end-stage pulmonary diseases. A limited donor supply has resulted in 4,000 patients on the waiting list. Currently, 10-20% of donor organs offered for transplantation are deemed suitable under the selection criteria, of which 15-25% fail due to primary graft dysfunction (PGD). This has spawned efforts to re-examine the current selection criteria as well as search for alternative donor lungs selection criteria. In this study, we attempt to furth  ...[more]

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