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Mineralocorticoid receptor (MR) trans-activation of inflammatory AP-1 signaling: dependence on DNA sequence, MR conformation, and AP-1 family member expression

ABSTRACT: Mineralocorticoid receptor (MR) primarily promote cardiovascular inflammation by incompletely understood mechanisms. The differential effects of GR and MR on inflammatory signaling and their contextual dependencies are relevant to the design of next generation drugs with improved safety and efficacy While MR has been shown to weakly repress NFκB, its role in modulating AP-1 has not been established

ORGANISM(S): Homo sapiens

PROVIDER: GSE80276 | GEO | 2016/09/20

SECONDARY ACCESSION(S): PRJNA318487

REPOSITORIES: GEO

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