Dataset Information


Expression data from yeast exposed to Caspofungin (wild type strain and rlm1, slt2, msn2/4 and bcy1 mutants) and Aminocandin (wild type strain)

ABSTRACT: We did transcription profiling on the effect of rlm1 (MAPK Slt2 transcription factor) deletion, slt2 (MAPK of Cell wall intregity pathway) deletion, bcy1 (Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA)) deletion and msn2/4 (Stress-responsive transcriptional activators) deletion in genes involved in Caspofungin response (2 hours of treatment). In addition, we analyzed the genome-wide expression profile of the wild type strain in response to Aminocandin (2 hours of treatment). Overall design: For Caspofungin treatment, six biological samples for wild type strain, three biological samples for rlm1, slt2 and msn2/4 mutants and two biological samples for bcy1 mutant were analyzed . Two biological samples were analyzed for wild type strain in response to Aminocandin. Two microarray experiment were carried out for each biological sample: 1. absence of the drug 2. presence of 15 ng/ml of Caspofungin or Aminocandin for two hours

INSTRUMENT(S): [Yeast_2] Affymetrix Yeast Genome 2.0 Array

SUBMITTER: Javier Arroyo  

PROVIDER: GSE80394 | GEO | 2017-01-31



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