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Characterization of nucleolus-associated domains in mus musculus and their dynamics after inactivation of the Upstream binding factor protein

ABSTRACT: Nucleolus-associated DNA was isolated from MEF cells before and after conditional knock-out of UBF and hybridized against genomic DNA in biological replicates. Two different types of immortalized MEF cells were used. MEFs were immortalized by genetic depletion of p53, iMEFs were immortalized by transfection of the SV40 Tt antigen.

ORGANISM(S): Mus musculus

PROVIDER: GSE80441 | GEO | 2018/02/02

REPOSITORIES: GEO

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Mapping nucleolus-associated chromatin interactions by nucleolus-Hi-C reveals repression network

Project description:Nucleolus plays a key role in organizing global nuclear structure and facilitating gene regulation, but the three dimensional information within the nucleolus associated chromatins are still unknown, so here we development the Nucleolus Hi-C (NHi-C) experimental technique, which combines the nucleolus isolation with Hi-C experiment, and study the interactions within and surrounding nucleolus in human cells with a high resolution. With NHi-C experiment, we report how the nucleolus-associated chromatin regions interact at genome scale, and how these interactions organize the repressive nucleus architecture.

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