Transcriptomics,Genomics

Dataset Information

29

Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans


ABSTRACT: Cell-cycle transcript dynamics from two species of wild-type budding yeast growing at 30 degrees Celsius in rich media: Saccharomyces cerevisiae (BF264-15D background) and Cryptococcus neoformans var. grubii (H99F background). We compared programs of cell-cycle-regulated genes between distantly related budding yeasts. Overall design: One time course experiment for each yeast over multiple cell cycles

INSTRUMENT(S): Illumina HiSeq 2500 (Saccharomyces cerevisiae)

SUBMITTER: Steven Haase  

PROVIDER: GSE80474 | GEO | 2016-12-07

SECONDARY ACCESSION(S): PRJNA319029

REPOSITORIES: GEO

altmetric image

Publications

Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans.

Kelliher Christina M CM   Leman Adam R AR   Sierra Crystal S CS   Haase Steven B SB  

PLoS genetics 20161205 12


The pathogenic yeast Cryptococcus neoformans causes fungal meningitis in immune-compromised patients. Cell proliferation in the budding yeast form is required for C. neoformans to infect human hosts, and virulence factors such as capsule formation and melanin production are affected by cell-cycle perturbation. Thus, understanding cell-cycle regulation is critical for a full understanding of virulence factors for disease. Our group and others have demonstrated that a large fraction of genes in Sa  ...[more]

Similar Datasets

2013-07-01 | E-MTAB-1700 | ArrayExpress
| GSE37875 | GEO
2013-05-31 | E-GEOD-37875 | ArrayExpress
2012-08-23 | E-GEOD-40303 | ArrayExpress
2009-05-01 | GSE11390 | GEO
2010-05-19 | E-GEOD-11390 | ArrayExpress
| PRJNA230886 | ENA
2009-09-26 | GSE17338 | GEO
2010-04-23 | GSE21484 | GEO
2010-04-23 | E-GEOD-21484 | ArrayExpress