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Expression analyses of glioblastoma derived neurosphere cultures

ABSTRACT: Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We established glioblastoma stem-like (GS-) cell cultures from 9 different glioblastomas, 8 of which generated stably expandable cell lines. Analyzing GS-cell cultures, we discovered two clearly discernable phenotypes. Microarray analysis showed that the 4 GSf cell lines shared expression profiles dominated by genes involved in nervous system development and neuropeptide signaling, while the 5 GSr lines shared expression signatures enriched for extracellular matrix-proteins. Keywords: Cell line comparison

ORGANISM(S): Homo sapiens

PROVIDER: GSE8049 | GEO | 2007/12/04

SECONDARY ACCESSION(S): PRJNA100875

REPOSITORIES: GEO

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